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Necrosis of hips and joints : A serious complication of long-term use of corticosteroids is aseptic necrosis of the hip joints, of which the most common complication is arthritis and the most frequent cause is prednisone-induced toxicity. : A serious complication of long-term use of corticosteroids is aseptic necrosis of the hip joints, of which the most common complication is arthritis and the most frequent cause is prednisone-induced toxicity. Increased risk of heart abnormalities in the elderly : With long-term corticosteroid use, people over the age of 50 should consult their physician before becoming immunocompromised. : With long-term corticosteroid use, people over the age of 50 should consult their physician before becoming immunocompromised. Increased risk of cancer in immunocompromised persons : When administered routinely to humans, corticosteroids result in increased risks of many cancers. : When administered routinely to humans, corticosteroids result in increased risks of many cancers. Increase of risk of lung function loss: Long-term use of corticosteroids might also result in decreased lung function, especially because of persistent systemic effects even if only transiently. As a general rule, those subjects with a history of respiratory disorders or COPD should be advised to take prednisone during asthma or acute lung injury treatment. Long-term use of corticosteroids may be associated with an increased risk of other serious adverse reactions, as well as increased mortality. More than 3,200 cases of anaphylactic shock, anaphylactic shock associated with inhaled corticosteroids, and anaphylactic shock associated with inhaled steroid treatment have previously been documented. See the Clinical Pharmacology section for a list of potential adverse reactions and appropriate precautions. Related Article: